Excess Iron – The Iron Overload Resource for International HCPs

Signs of iron overload (also known as excess iron) may be seen after as few as 10 red blood cell transfusions, making iron overload a common secondary disease among transfusion-dependent patients. Patients with chronic severe anemias caused by thalassaemia, sickle cell disease, and myelodysplastic syndromes requiring blood transfusions are at greatest risk.

The most common cause of iron overload is hereditary haemochromatosis, a condition linked to a mutation of the HFE gene. Among untreated homozygous patients, the disorder typically leads to significant iron overload by the 4th or 5th decade of life.

Excessiron.com, your excess iron resource, helps keep you informed with the latest news on
haematology and iron overload.

The Global Iron Summit was held November 2-3, 2007 in Frankfurt, Germany, Click here to view the Summit agenda, faculty presentations and bios.

Bernard-Soulier syndrome: novel nonsense mutation in GPIbbeta gene affecting GPIb-IX complex expression
Does the SLC40A1 gene modify HFE-related haemochromatosis phenotypes?
Deep vein thrombosis after total hip arthroplasty in Korean patients and D-dimer as a screening tool

Deferasirox Treatment Improved the Hemoglobin Level and Decreased Transfusion Requirements in Four Patients with the Myelodysplastic Syndrome and Primary Myelofibrosis
Pharmacokinetics of oral posaconazole in neutropenic patients receiving chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome